Leeds Institute of Cancer and Pathology

Pre-Cancer Genomics

Manar Samman – PhD student

Contact Information

Manar Samman
Pre-Cancer Genomics
Leeds Institute of Cancer and Pathology
St James’s University Hospital
Faculty of Medicine and Health
University of Leeds

tel: +44 7832077709





I am currently doing my PhD project in: “The Genomic Landscape of Oral Verrucous Carcinoma”. Supervised by Prof. Pamela Rabbits and Dr. Alec High.

In particular, I am working on oral verrucous carcinoma samples (OVC): a low grade, non-metastasising, slow growing variant of oral squamous cell carcinoma (OSCC), with an estimated incidence range between 2%-10% of all OSCC cases. In general, OVC histopathological diagnosis is ambiguous and difficult. Distinction of OVC from classical OSCC is a common problem for pathologists due to the poorly defined diagnostic criteria and sampling difficulties. Early OVC usually presents as a pre-malignant lesion such as Oral verrucous hyperplasia (OVH). OVH lesions may transform into either an OVC or an OSCC. The genomic alterations underlying OVH, and OVC lesions is still not clear and requires further investigations. The rarity of these lesions also makes them difficult to investigate, so most previous studies have been made on small numbers of cases.

Aims and objectives

Brief Resume


Next-Generation Sequencing Analysis for Detecting Human Papillomavirus in Oral Verrucous Carcinoma. Manar Samman; Henry M Wood; Caroline A Conway; Stefano Berri; Monica Pentenero; Sergio Gandolfo; Adele Cassenti; Paola Cassoni; Abdulaziz Al Ajlan; William A Barrett; Preetha Chengot; Pamela Rabbitts; Alec S High, FRCPath; Kenneth MacLennan, MD FRCPath. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2014 Jul;118(1):117-125
Pubmed link

PP066: No association between human papillomavirus infection and oral verrucous lesions. Manar Samman, Henry Wood, Stefano Berri, Monica Pentenero, Alec High, Pamela Rabbitts. Oral Oncology 49. May 2013. PS116. Link


1st Prize – Poster Presentation: Next Generation Sequencing (NGS): a powerful tool providing new insights into the genomic landscape of Oral Verrucous Carcinomas. 7th Saudi Students Conference – UK. 2014. More details.

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