Manar Samman – PhD student
Leeds Institute of Cancer and Pathology
St James’s University Hospital
Faculty of Medicine and Health
University of Leeds
tel: +44 7832077709
I am currently doing my PhD project in: “The Genomic Landscape of Oral Verrucous Carcinoma”. Supervised by Prof. Pamela Rabbits and Dr. Alec High.
In particular, I am working on oral verrucous carcinoma samples (OVC): a low grade, non-metastasising, slow growing variant of oral squamous cell carcinoma (OSCC), with an estimated incidence range between 2%-10% of all OSCC cases. In general, OVC histopathological diagnosis is ambiguous and difficult. Distinction of OVC from classical OSCC is a common problem for pathologists due to the poorly defined diagnostic criteria and sampling difficulties. Early OVC usually presents as a pre-malignant lesion such as Oral verrucous hyperplasia (OVH). OVH lesions may transform into either an OVC or an OSCC. The genomic alterations underlying OVH, and OVC lesions is still not clear and requires further investigations. The rarity of these lesions also makes them difficult to investigate, so most previous studies have been made on small numbers of cases.
Aims and objectives
- To use next generation sequencing (NGS) copy number analysis to identify OVC genomic characteristic features, and distinguish between the genomic damage pattern in OVH, OVC, and OSCC lesions.
- To analyse all oral verrucous lesions for the presence of HPV subtypes and all known human viral genomes.
- To use RNA sequencing to investigate transcriptional changes that occur in OVC and compare them with the changes that occur in OSCC.
- To identify candidate genes associated with OVC and distinguish between them and candidate genes associated with OSCC using targeted exome capture.
- Bachelor of Science degree in clinical laboratory from (2000-2004) at King Saud University, Riyadh, Saudi Arabia, College of Medical Applied Science.
- Four years of working experience from 2004 in Cytogenetics lab at King Fahad Medical City/ Saudi Arabia.
- MSc degree with merit in biological science (human genetics) from (2009-2010) at University of Leeds/ UK.
- PhD project started in Jan. 2011, and expected to finish in 2014.
Next-Generation Sequencing Analysis for Detecting Human Papillomavirus in Oral Verrucous Carcinoma. Manar Samman; Henry M Wood; Caroline A Conway; Stefano Berri; Monica Pentenero; Sergio Gandolfo; Adele Cassenti; Paola Cassoni; Abdulaziz Al Ajlan; William A Barrett; Preetha Chengot; Pamela Rabbitts; Alec S High, FRCPath; Kenneth MacLennan, MD FRCPath. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology. 2014 Jul;118(1):117-125
PP066: No association between human papillomavirus infection and oral verrucous lesions. Manar Samman, Henry Wood, Stefano Berri, Monica Pentenero, Alec High, Pamela Rabbitts. Oral Oncology 49. May 2013. PS116. Link
- A ceremony was held on the 23rd of September, 2014, at the Royal Embassy of Saudi Arabia in London, honouring 100 students for their distinct discoveries and successes in British universities. More details.
- During the tribute, Prince Mohammed bin Nawaf bin Abdulaziz, presented Manar Samman with an award for being one of the top ten Saudi students currently studying in the UK.
- According to the latest statistics in 2014, more than 14,000 Saudi students study in the UK.
1st Prize – Poster Presentation: Next Generation Sequencing (NGS): a powerful tool providing new insights into the genomic landscape of Oral Verrucous Carcinomas. 7th Saudi Students Conference – UK. 2014. More details.