Leeds Institute of Cancer and Pathology

Pre-Cancer Genomics

Pamela Rabbitts – Professor of Experimental Respiratory Research

Contact Information

Professor Pamela Rabbitts
Section of Pre-Cancer Genomics
Leeds Institute of Cancer and Pathology
Wellcome Trust Brenner Building
St James’s University Hospital
LS9 7TF, Leeds
United Kingdom

tel: +44 (0) 113 3438613
email: p.rabbitts@leeds.ac.uk




Pamela Rabbitts is Professor of Experimental Respiratory Research and group leader of the Pre-cancer Genomics Group in the Section of Experimental Therapeutics in the Leeds Institute of Cancer Studies and Pathology (LICSP). She held appointments in Cambridge and UCL before joining LIMM in 2006. Her research investigates the relationship between genes, chromosomal abnormalities and cancer phenotypes and has involved technology development, for example, mouse chromosome paints and recapitulation of human tumour chromosomal aberrations in mouse models. It is supported by YCR, CR-UK and EU funding. Working closely with clinicians has always been a characteristic of her research in order to relate her investigations to real clinical problems. It is for this reason that the genomic analysis of pre-cancer has become the focus of her work within the last fifteen years as the early detection of cancer is recognised as an important approach to reduce cancer-related mortality. Her contribution to translational research was acknowledged by her election in 2007 to the Academy of Medical Sciences.

Current projects relate to revealing the differences between the genomes of pre-cancer (dysplasia) and fully malignant tumours to identify biomarkers of early disease in tumours of the upper aero-digestive tract. The genomes are being analysed by copy number variation, whole genome sequencing and transcriptomics.


Noteworthy publications for Pamela Rabbitts

Genomic evidence of preinvasive clonal expansion, dispersal and progression in bronchial dysplasia. 
Frank McCaughan, Christodoulos P Pipinikas, Sam M Janes, P Jeremy George, Pamela H Rabbitts and Paul H Dear.
 Journal of Pathology 2011; 224 153-9

Using next-generation sequencing for high resolution multiplex analysis of copy number variation from nanogram quantities of DNA from formalin-fixed paraffin-embedded specimens. 
Henry M. Wood; Ornella Belvedere; Caroline Conway; Catherine Daly; Rebecca Chalkley; Melissa Bickerdike; Claire McKinley; Phil Egan; Lisa Ross; Bruce Hayward; Joanne Morgan; Leslie Davidson; Ken MacLennan; Thian K. Ong; Kostas Papagiannopoulos; Ian Cook; David J. Adams; Graham R. Taylor; Pamela Rabbitts. 
Nucleic Acids Research 2010; doi: 10.1093/nar/gkq510

Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer.
 Frank McCaughan, Jessica CM Pole , Alan T Bankier, Bernard A Konfortov, Bernadette Carroll, Mary Falzon, Terence H Rabbitts, P Jeremy George, Paul H Dear P, and Pamela H Rabbitts.
 Am J Respir Crit Care Med. 2010; 182:83-91

µMCC – Unlocking Cancer Archives with Digital PCR. 
McCaughan F, Darai-Ramqvist E, Bankier AT, Konfortov B, Foster N, George PJ, Rabbitts T, Kost-Alimova M, Rabbitts PH and Dear PH.
 Journal of Pathology. 2008; 216 307-16

Targeted disruption of the 3p12 gene, Dutt1/Robo1, predisposes mice to lung adenocarcinomas and lymphomas with methylation of the gene promoter. Xian J, Aitchison A, Bobrow L, Corbett G, Pannell R, Rabbitts T, Rabbitts P.
Cancer Res. 2004;64:6432-7

Cre-loxP chromosome engineering of a targeted deletion in the mouse corresponding to the 3p21.3 region of homozygous loss in human tumours. Andrew J.H. Smith, Jian Xian, Melville Richardson Karen A. Johnstone and Pamela H Rabbitts.
Oncogene (2002) 21 4521-4529

A site-directed chromosomal translocation induced in embryonic stem cells by Cre-loxP
recombination. Smith AJ, De Sousa MA, Kwabi-Addo B, Heppell-Parton A, Impey H, Rabbitts P.
Nat Genet 1995 9 376-385

Chromosome specific paints from a high resolution flow karyotype of the mouse. Rabbitts P, Impey H, Heppell-Parton A, Langford C, Tease C, Lowe N, Bailey D, Ferguson-Smith M, Carter. 
Nat Genet 1995 9 369-375

PCR-based RFLP analysis allows genotyping of the short arm of chromosome 3 in small
biopsies from patients with lung cancer. Ganly PS, Jarad N, Rudd RM, Rabbitts PH.
Genomics 1992 12 221-8

Inadequate lung development and bronchial hyperplasia in mice with a targeted deletion in the Dutt1/Robo1 gene. Xian J, Clark KJ, Fordham R, Pannell R, Rabbitts TH, Rabbitts PH.
 Proc Natl Acad Sci U S A. 2001 Dec; 98:15062-6

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